Thirty‐two genes (GRAMD3, SYNGR1, CMTM7, HLA‐DMB, HLA‐DRB4, CLEC2D, CCNB1IP1, HLA‐DRA, DEFB1, ERBB2, MUC4, LOC145837, RPS24, RHOD, HBEGF, ARHGDIB, PITPNC1, PEA15, KRT16, GJB3, JUN, FHL2, CYB5R2, HLA‐B, EGR2, HERC6, DUSP5, HBA2, CHST15, NKX3‐1, LBH, TSPAN8) are common in hypopharyngeal cancer and EGFR‐mutated lung adenocarcinoma. Here, DEFB1 is linked to lung adenocarcinoma.