Thirty‐two genes (GRAMD3, SYNGR1, CMTM7, HLA‐DMB, HLA‐DRB4, CLEC2D, CCNB1IP1, HLA‐DRA, DEFB1, ERBB2, MUC4, LOC145837, RPS24, RHOD, HBEGF, ARHGDIB, PITPNC1, PEA15, KRT16, GJB3, JUN, FHL2, CYB5R2, HLA‐B, EGR2, HERC6, DUSP5, HBA2, CHST15, NKX3‐1, LBH, TSPAN8) are common in hypopharyngeal cancer and EGFR‐mutated lung adenocarcinoma. The gene discussed is CYB5R2; the disease is hypopharynx cancer.