Furthermore, KPT‐330 has been shown to mediate the nuclear retention of E2F7, leading to the repression of SPHK1, which in turn increases anthracycline sensitivity119 These findings reveal some of the mechanisms underlying anthracycline resistance and provide new treatment strategies that warrant further clinical evaluation in patients with HNSCC and osteosarcoma. Here, E2F7 is linked to head and neck squamous cell carcinoma.