Among the CAF subsets in cancer [81], antigen-presenting fibroblasts, which are characterized by high expression of MHCII molecules and CD74 and can present antigens to T cells [82], were also found to be expanded in RA (CD90+HLA-DRAhigh FLS) [70]; these results suggest potential new therapeutic strategies based on targeting CD74 on fibroblasts [83]. This evidence concerns the gene CD74 and rheumatoid arthritis.