To dissect the potential role of neuronal Lrp4 in the development of epilepsy, we generated pyramidal neurons-specific Lrp4 mutant mice by crossing Lrp4f/f mice with Nex::Cre mice (Fig. 2A), in which Cre expression is under control of Nex promoter and restricted to pyramidal neurons of the dorsal telencephalon [31]. Here, LRP4 is linked to epilepsy.