In contrast, we report that specific knockdown of Lrp4 in the astrocytes of the hippocampus duplicated the phenotypes of brain-wide Lrp4 mutant mice (hGFAP-Lrp4−/−), demonstrating that astrocytic Lrp4 in the hippocampus is critical in regulation of the development of SE-induced epilepsy. Here, LRP4 is linked to epilepsy.