The model with tumor CT features showed that tumor located in ILA (OR = 0.156, 95% CI: 0.046–0.529; p = 0.003) and tumor diameter (OR = 0.592, 95% CI: 0.415–0.846; p = 0.004) were independent predictors of EGFR mutation; the corresponding AUC value was 0.838 (95% CI: 0.754–0.922, p < 0.001). The gene discussed is EGFR; the disease is neoplasm.