When combining the three models, the significantly independent predictors for EGFR mutation were subpleural fibrotic ILA (OR = 0.169, 95% CI: 0.030–0.964; p = 0.043), sex (OR = 0.141, 95% CI: 0.035–0.557; p = 0.005) and tumor diameter (OR = 0.637, 95% CI: 0.429–0.944; p = 0.025), giving a predictive value for EGFR mutations with the AUC value of 0.920 (95% CI: 0.861–0.978, p < 0.001), a diagnostic sensitivity of 90.9% and a specificity of 86.2% (Fig. 4). Here, EGFR is linked to neoplasm.