The AR response include high amounts of specific IgE in the serum, high amounts of allergy relative mediators (eosinophil peroxidase and tryptase), and Th2 cytokines (IL-4, IL-5, IL-13) in nasal secretions, and high total nasal symptom scores (TNSS) (Fig. 2A). This evidence concerns the gene IL5 and allergic disease.