These aberrations occur in around 20–25% of T-ALL, and the TLX3 gene is aberrantly activated by various cryptic translocations, including t(5;14)(q35;q32), which juxtapose TLX3 with BCL11B, a gene expressed during T-cell maturation [25, 34, 35]. The gene discussed is BCL11B; the disease is acute lymphoblastic leukemia.