More recently, have been seeing that natural acquired antibodies against P. vivax PE CelTOS, SPECT1, SSP3 and CSP proteins achieved significant inhibitory activity into formation of exoerythrocytic forms (EEFs) in in-vitro sporozoite-hepatocyte infection model, suggesting an important role of naturally acquired humoral immunity over the development of EEFs in P. vivax infected patients [34, 35]. This evidence concerns the gene SENP3 and infection.