INS and obesity due to melanocortin 4 receptor deficiency: The proportion of obesity (23.1% vs. 19.8%, p < 0.001), contraceptive use (1.03% vs. 0.33%, p < 0.001), PCOS (1.64% vs. 0.55%, p < 0.001), infertility (0.52% vs. 0.04%, p < 0.001), anemia (15.7% vs. 8.5%, p < 0.001), NSAIDs (1.09% vs 0.71% p < 0.001), and leiomyoma uterus (51.5% vs. 1.3%, p < 0.001) were significantly higher in HMB hospitalizations than in NMC group whereas MS, individual components of MS, insulin use, IBD, and DM were significantly lower in HMB compared to NMC (Table 1).