The proportion of obesity (23.1% vs. 19.8%, p < 0.001), contraceptive use (1.03% vs. 0.33%, p < 0.001), PCOS (1.64% vs. 0.55%, p < 0.001), infertility (0.52% vs. 0.04%, p < 0.001), anemia (15.7% vs. 8.5%, p < 0.001), NSAIDs (1.09% vs 0.71% p < 0.001), and leiomyoma uterus (51.5% vs. 1.3%, p < 0.001) were significantly higher in HMB hospitalizations than in NMC group whereas MS, individual components of MS, insulin use, IBD, and DM were significantly lower in HMB compared to NMC (Table 1). This evidence concerns the gene INS and Uterine leiomyoma.