In our study, although not statistically significant, females possessed a lower BMI than males, previous studies have shown that neuroinflammation may be a modifiable pathway linking obesity and depression [78], and obesity may trigger persistent epigenetic changes in innate immunity and exacerbates neuroinflammation, which may explain why our findings showed lower S100B in females [79]. This evidence concerns the gene S100B and obesity due to melanocortin 4 receptor deficiency.