For instance, variants in genes such as NRXN1, SCN1A, PTEN, TBCD, ARFGEF1, GNAI1, SYNGAP1, GRIN2A, SPTBN5, and CNTNAP2 have been linked to epilepsy as well as neurobehavioral and neurodevelopmental comorbidities or other related symptoms [1, 6–15]. Here, SPTBN5 is linked to epilepsy.