Homozygous variants in ZFYVE26 have been reported to cause autosomal recessive hereditary spastic paraplegia (AR HSP), which is characterized by progressive spasticity and weakness of the lower limbs, often accompanied by cognitive impairment and a thin corpus callosum on magnetic resonance imaging (MRI) scans [40–42]. Here, ZFYVE26 is linked to hereditary spastic paraplegia.