One such test is the Oncotype DX GPS assay, which detects the expression of 12 genes (BGN, COL1A1, SFRP4, AZGP1, KLK2, SRD5A2, FAM13C, FLNC, GSN, GSTM2, and TPM2, TPX2) associated with prostate cancer aggressiveness, along with 5 housekeeping genes (RF1, ATP5E, CLTC, GPS1, and PGK1) [25]. The gene discussed is PGK1; the disease is prostate cancer.