MCCC2 may play a dual role in this process: on one hand, it contributes to providing essential biosynthetic raw materials for tumor cells by participating in the metabolism of branched-chain amino acids; on the other hand, aberrant expression or function of MCCC2 may be associated with the metabolic reprogramming of tumor cells, affecting tumor growth and development (Meierhofer et al. 2016; Liu et al. 2023). The gene discussed is MCCC2; the disease is neoplasm.