Yao Yang et al. found that ECHDC2 can be used as an independent prognostic indicator of HBV-associated HCC, and the lipid metabolism and other related pathways were significantly enriched in the ECHDC2 group with high expression (Yang et al. 2018).Lindsay J Wheeler et al. used a multi-omics approach to identify ECHDC2 regulation of fatty acid metabolism in ovarian cancer (Wheeler et al. 2019). This evidence concerns the gene ECHDC2 and hepatocellular carcinoma.