The GPR model is a novel noninvasive assessment model for apparent cirrhosis in chronic HBV-infected patients proposed recently by Lemoine et al., and the degree of liver fibrosis was assessed using both GGT and PLT data.24 This study showed that the GPR had significant differences between advanced fibrosis group and control group, with significantly higher GPR was observed in advanced fibrosis group. This evidence concerns the gene ALDH18A1 and fibrosis.