TLR8 and rheumatoid arthritis: Likewise, for rheumatoid arthritis (RA), our work makes a plausible link between exRNA in synovial fluid contributing to joint inflammation (Neumann et al, 2018), the emerging role of NETs in RA (Song et al, 2020) and even a hitherto enigmatic but therapeutically relevant role of TLR8 (Sacre et al, 2016; Sacre et al, 2008).