APC and colorectal cancer: For instance, SKCM had specific mutations in BRAF that were driven by ultraviolet light exposure; IDH1 mutation, which was reported as molecular markers in gliomas28, were uniquely identified in LGG; APC was frequently mutated in colorectal cancers (COAD and READ), which was considered a key factor in colorectal tumorigenesis29; CTNNB1 in the Wnt/β-catenin pathway was highly mutated in LIHC.