While TNF or TNFR1 co-deletion together with co-deletion of ZBP1, significantly ameliorated colon inflammation, by preventing MLKL-induced necroptosis, this is not sufficient to prevent ileitis, where it was proposed that Casp8 also drives Gasdermin-D-mediated pyroptosis of FADD-deficient intestinal epithelial cells which contributes to the observed inflammatory phenotype [35, 67]. Here, TNF is linked to Crohn ileitis.