AQP4 and multiple sclerosis: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a demyelinating disorder of the central nervous system (CNS) distinct from multiple sclerosis (MS) and aquaporin 4 (AQP4) immunoglobulin G (IgG) antibody-associated neuromyelitis optica spectrum disorder (NMOSD).