By establishing the correlation network of differential RBPs and differential AS events, we found that RBM47, PCBP3, FRG1, SRP72, RBMS3 and other RBPs may regulate the AS of ITGA6, ADGRE5, TNC, COL6A3 and other cell adhesion genes, which may affect the EMT process of breast cancer cells. The gene discussed is ADGRE5; the disease is breast cancer.