POLE and colorectal carcinoma: For predicting POLE p.P286R mutations, our model reached a comparable or even better prediction scores (mean ± standard deviation) than calculated for all driver mutations in TCGA (0.96 ± 0.04), APHP resection (0.70 ± 0.29) and APHP biopsy (0.73 ± 0.16), indicating that our algorithm is able to identify morphological features associated with this particular CRC-specific POLE mutation.