On the other hand, pathways associated with anti-tumor immune response (e.g., interferon-gamma response, T cell receptor signaling, natural killer cell-mediated cytotoxicity, antigen processing and presentation, Th1/Th2 cell differentiation, and toll-like receptor signaling) were enriched among the top down-regulated signaling axes (Fig. 3b), which may explain, in part, the poor effectiveness of immunotherapies against MYC-driven malignancies70. This evidence concerns the gene IFNG and neoplasm.