Our findings reveal a significant correlation between the expression of ARHGAPs genes and the immune markers of tumor-associated macrophages (TAM), M1 and M2 macrophages, as well as subgroups of CD4 + T cell differentiation, including Th1, Th2, Tfh, Th17, and Treg cells (supplementary materials Table S4). This evidence concerns the gene CD4 and neoplasm.