FAT1 and central nervous system cancer: One study reports that the expression of FAT1 is positively correlated with that of TGFβ1/2 in human gliomas, primary glioma cultures, and other cancer cell lines (U87MG, HepG2, Panc-1, and HeLa cells), and that FAT1 silencing results in decreased expression and secretion of TGFβ1/226.