Although mutations and deletion of FAT1 are associated with tumorigenesis in some malignancies such as skin squamous cell carcinoma, lung cancer, head and neck squamous cell carcinoma, and oral cancer6–9, in other cancers, such as breast carcinoma, colorectal cancer, hepatocellular carcinoma, cervical cancer, pancreatic cancer, and gliomas, FAT1 exhibits an oncogenic role10–15. The gene discussed is FAT1; the disease is head and neck squamous cell carcinoma.