Transmission electron microscopy results showed significant structural abnormalities in the myocardial tissue of Ddx17-cKO mice, which mainly manifested as disorganized myocardial tissue structure, markedly increased myocardial fibrosis, disorganized mitochondrial arrangement, smaller mitochondria, and loose mitochondrial structure (Fig. 4a). Here, DDX17 is linked to Myocardial fibrosis.