Research on DDX17 has mainly focused on oncology studies, including tumorigenesis and tumor progression in colon cancer and breast cancer.3–5 DDX17 is abundantly expressed in cardiomyocytes and has been shown to be potentially involved in the development of cardiac hypertrophy and doxorubicin-induced cardiomyocyte injury in vitro.6,7 However, the function of DDX17 in cardiomyocytes and its role in the development of heart failure remain unclear. This evidence concerns the gene DDX17 and heart failure.