Consistent with these structural changes, the left ventricular EF of patients with heart failure showed a significant positive correlation with the mRNA level of DDX17 (r = 0.5644, P = 0.0284) and a negative correlation with the mRNA level of DRP1 (r = −0.6526, P = 0.0074) in myocardial tissue (Fig. 6d, e). Here, DDX17 is linked to heart failure.