Recent studies have shown that eIF3a may act alone or in complex with other eIF3 subunits necessary for translation initiation.22 In addition to regulating translation, an increasing number of studies have confirmed that eIF3a is implicated in cell cycle progression, cell differentiation, as well as DNA synthesis and repair.6,7 eIF3a can promote the migration of CRC by upregulating Cdc42 and RhoA expression at the translational level.12 Still, the specific molecular mechanisms through which eIF3a promoted CRC malignancy has never been investigated in depth. The gene discussed is CDC42; the disease is colorectal carcinoma.