The PI3K-AKT signaling pathway is among the commonly dysregulated signaling cascades in tumors, controlling cell growth, proliferation, differentiation, apoptosis, invasion, metastasis, and the EMT.23 Studies on other subunits of eIF3 have revealed that eIF3b, eIF3d, and eIF3c all promote tumor progression through PI3K/AKT signaling.24–26 Thus, PI3K/AKT may also be regulated downstream of eIF3a. The gene discussed is AKT1; the disease is neoplasm.