TSA inhibited expression of interferon pathway genes (IFIT2, STAT1, IRF7, XAF1 and IRAK1), inflammation-related genes (MYD88, NF-κB, ICAM and PTPN2), chemokines and inflammatory cytokines (CXCL11, CCL2, IL-6 and CXCL8) and migration- and invasion-related genes (MMP13, PDGFR and MMP1) in RA-FLSs (Fig. S8A–D). The gene discussed is IRAK1; the disease is rheumatoid arthritis.