BAs can activate a plethora of receptors (reviewed in [30]) and similar pathways may play a role in inducing LCA-mediated antineoplastic programs in other cancers (e.g. colon cancer [54]), but different receptors may be activated in other neoplasias to elicit cytostasis (e.g. TGR5 and CAR receptors in breast cancer [9]). The gene discussed is GPBAR1; the disease is Leber congenital amaurosis.