For example, MMP13 (Matrix Metalloproteinase 13) secreted by fibroblasts promotes tumor angiogenesis [27], while MMP2 (Matrix Metalloproteinase 2) and MMP9 (Matrix Metalloproteinase 9) degrade ECM (Extracellular Matrix) components to promote metastasis [28]. The gene discussed is MMP13; the disease is neoplasm.