NKILA (NF-κB Interacting Long Noncoding RNA Antisense to NF-κB p65) mediates the phosphorylation of I-κB α and the translocation of NF-κB to the nucleus, thereby reducing the expression of MMP14 (Matrix Metalloproteinase 14), impairing the migration and invasion of ESCC (Esophageal Squamous Cell Carcinoma) cells [31]. This evidence concerns the gene NFKB1 and esophageal squamous cell carcinoma.