GPT and intracranial hemorrhage: By comparing the outcomes of all adult patients treated with ALT in the New Zealand Central Region from January 1 2018 to March 1 2020 with those treated with TNK from March 2 2020 to February 14 2021, it was found that the functional independence at 90 days after switching from ALT to TNK was improved and there was no increase in symptomatic intracranial hemorrhage (ICH, sICH) [21].