Elucidating how ERLIN complexes interact with different E3 ubiquitin ligases and determining the cellular processes controlled by the ERLIN complexes are crucial, because mutations in ERLIN1 or ERLIN2 gene have been associated with motoneuronal diseases, such as hereditary spastic paraplegia (HSP), primary lateral sclerosis, and amyotrophic lateral sclerosis (Alazami et al, 2011; Yildirim et al, 2011; Al-Saif et al, 2012; Wakil et al, 2013; Rydning et al, 2018; Tunca et al, 2018; Park et al, 2020; Srivastava et al, 2020; Kume et al, 2021; Qiao et al, 2022). This evidence concerns the gene ERLIN1 and hereditary spastic paraplegia.