GFAP aggregates in the form of RFs bear strong similarities to other IF-specific inclusions that represent hallmarks of various IF-associated diseases (46), including keratins in Mallory-Denk bodies of liver diseases (47), desmin in granulofilamentous materials of desmin-related myopathies (48), and neurofilaments in Lewy bodies of Parkinson’s disease (49). This evidence concerns the gene DES and liver disorder.