However, a significant decrease in CD3+CD4+CD25HighCD39+CD73+ cells was noted in the endometriosis group (M: 1.98; IQR: 0.0377–3.17 vs. M: 1.25; IQR: 0–5.08; p = 0.0483), suggesting a potential alteration in systemic immune tolerance mechanisms in endometriosis. This evidence concerns the gene NT5E and endometriosis.