However, a significantly lower frequency of CD3+CD4+CD25HighCD39+CD73+ cells was observed in the endometriosis group compared to controls (M: 1.98; IQR: 0.0377–3.17 vs. M: 2.25; IQR: 0.50–4.08; p = 0.0483), suggesting a reduction in systemic immune tolerance among these patients. The gene discussed is CD4; the disease is endometriosis.