Incident CVD, on the other hand, has been associated with CD45RA+ CD4+T cells (T effector memory expressing RA), senescent cells, and TH17 cells.203 Notably, this study found an increased association between CD4+ Treg and the ASCVD risk, which could have been a compensatory increase with systemic activation.203. This evidence concerns the gene CD4 and rheumatoid arthritis.