CCN2 and Hepatic fibrosis: In the hepatic fibrosis models, curcumin can significantly reduce HA, LN, Collagen I, Collagen III, PCIII, PIIINP, IV-C, TNF-α, α-SMA, HYP, PDGF-BB, CTGF and TGF-β1 to alleviate inflammatory response, inhibit HSC activation and proliferatsion, and regulate the imbalance of ECM synthesis and degradation.