The oxidative stress-related indicators in this study mainly include SOD, MDA, and GSH-Px.The results showed that curcumin can increase the levels of SOD and GSH-Px in hepatic fibrosis rats or mice models, and reduce MDA levels, it can increase SOD by 43.53U/mg (p<0.00001), GSH-Px by 32.14U/mg (p<0.00001), and reduce MDA by 7.77nmol/mg (p<0.00001). The gene discussed is SOD1; the disease is Hepatic fibrosis.