Thavendiranathan P et al. showed that anthracyclines can directly inhibit the adenylate-activated protein kinase signaling pathway and neuromodulin/ErbB signaling pathway in myocardial tissue, deplete the cardiomyocyte transcription factor GATA-4 and cardiac anchor chain repeat protein, induce activation and release of a series of inflammatory factors, inhibit transient and delayed outward potassium currents, and affect Na±Ca2+ exchange, leading to myocardial ischemia and hypoxia and bundle branch conduction system block and ultimately arrhythmia [23,24]. This evidence concerns the gene GATA4 and myocardial ischemia.