Out of the 14 TCGA cancers analyzed for the presence of NISCH promoter methylation, seven types showed significant increase in methylation levels in tumor samples with lower NISCH expression compared to the samples with higher NISCH expression: BLCA, LIHC, LUAD, KIRC, KIRP, PRAD, and TGCT (Fig 5E). Here, NISCH is linked to cancer.