NISCH and neoplasm: The majority of signaling pathways that were commonly enriched in the “NISCH low” phenotype in all the examined tumor types were related to the increased metabolic activity: glycolysis, mTORC1 signaling, oxidative phosphorylation, gluconeogenesis, tricarboxylic acid (TCA) cycle, fatty acid metabolism, adipogenesis and different amino acids metabolism pathways (Fig 6A).