PPARG and obesity due to melanocortin 4 receptor deficiency: Other enriched motifs in PPARγ overlapping sites were ELK1, which has been linked to obesity as a target of miRNAs involved in adipogenesis, with decreased expression in obese visceral adipose tissue (VAT) [54], and TP73, which alters glycolysis within the liver via regulation of G6PD and other metabolic enzymes [55].