Induced activation of FGFR1 leads to invasive adenocarcinoma with 100% penetrance after a 42-week treatment with chemical inducers of dimerization (42), and knockout of FGFR1 in transgenic adenocarcinoma of the mouse prostate (TRAMP) models result in attenuated tumorigenesis (43). Here, FGFR1 is linked to adenocarcinoma.