Furthermore, in the cocultures of CAFs and DU 145 cancer cells, the blockage of TNF-α by the neutralizing antibodies against TNF-α, TNFR1, and TNFR2 effectively eliminated the increase in Fgf9 secretion by CAFs caused by KLF5KR knockin (Figure 6I). This evidence concerns the gene TNFRSF1B and cancer.