PTEN and Familial prostate cancer: The expression level of Cx3cr1 was increased by Klf5KR knockin in Pten-deficient prostate cancer, as suggested by RNA-Seq (Figure 8A) and confirmed by IHC staining of prostate tissues from PBCrePten–/–Klf5KR/KR and PBCrePten–/–Klf5+/+ mice (Figure 8B).