FGFR1 and Familial prostate cancer: Functionally, knockdown of CX3CR1 suppressed the activation of FGFR1 signaling in DU 145 cells with KLF5WT and KLF5KR and attenuated the hyperactivation of FGFR1 signaling in KLF5KR-expressing prostate cancer cells (Figure 8D).