Previous studies have suggested oncogenic functions of CX3CR1 in prostate cancer, as the expression of CX3CR1 in prostate cancer epithelial cells directs their circulation to the bone (45, 46), and CX3CL1/CX3CR1 enhance the migration and metastasis of prostate cancer cells (47, 48). Here, CX3CL1 is linked to Familial prostate cancer.