Further pathological evaluation indicated that knockin of Klf5KR resulted in more proliferative cells in prostate tumors, as suggested by both the mitotic images and frequency of Ki67+ cells (Figure 2, C–E), but did not significantly altered the expression patterns of epithelial markers, such as Ar, Ck5, and Ck8 (Supplemental Figure 1C). Here, KRT8 is linked to prostate neoplasm.