CLEC4A and peritonitis: To fully exploit the ADCP and ADCC effects mediated by mouse Fc receptors CD16 and CD32, which are only partially activated by the human IgG1 Fc portion of our anti-DCIR mAbs due to suboptimal binding affinity (35), we generated an anti-DCIR mAb, clone 5E11, with mouse IgG2b (5E11-mIgG2b) and evaluated its efficacy in the ZymD-induced peritonitis model.