Since huDCIR highly expresses on neutrophils accumulated in the colon crypts of huDCIR-KI mice during DSS-induced colitis (Figure 4I), we analyzed the infiltrated neutrophil activation and the integrity of crypts by CLE and found that administration of agonistic anti-DCIR mAb (9D9) decreased neutrophil elastase staining (NE680) and increased integrity of crypts (Figure 7D and Supplemental Videos 3–6). The gene discussed is ELANE; the disease is colitis.