Among 266 cases with a confirmed HL origin (266), 45.1% (120) had HL of genetic origin, of which 50.0% (60) were syndromic (the most frequent being Usher and Waardenburg syndromes) and 50.0% (60) were nonsyndromic (the most frequent being associated with connexin 26). This evidence concerns the gene GJB2 and Hodgkins lymphoma.