GYPA and non-small cell lung carcinoma: To sum up, as far as we know, this is the first study to report the promising efficiency of PD-1 and TMZ in NSCLC with brain metastasis together with lower cytotoxicity, further study exhibited that the efficiency of such regimen correlate with Ds-GPA score, indicating that Ds-GPA score can be utilized as a potential parameter for efficiency prediction of such regime (Sperduto et al. 2010).