GRK2 (G Protein-Coupled Receptor Kinase 2), a central signalling node that modulates G protein-coupled receptors (GPCRs) and other cell signalling routes including the NF-KB and MAPK inflammatory pathways, is a critical regulator of chemotaxis [103] and myeloid-specific deficiency of GRK2 results in excessive cytokine production in a sepsis model [104]. Here, GRK2 is linked to Sepsis.