TLR4 and infection: In M1 pro-inflammatory-like macrophages, m6A was found in transcripts that are highly expressed and translated during macrophage response to infection including TLR4 (Toll-Like Receptor 4) [82], ICAM1 (Intracellular Adhesion Molecule 1) [83] and YAP1 (Yes-associated protein 1) [84] (Figs. 3D, 3E and S3B).