Canalicular and sinusoidal staining for CD10, CD34, and pCEA (polyclonal CEA), along with reticulin framework disintegration, is also characteristic of HCC, as is nuclear positivity for hepatocyte nuclear factor 4 alpha (HNF4a) (Brunt et al. 2015; Gurzu et al. 2015). This evidence concerns the gene CEACAM5 and hepatocellular carcinoma.