AFP and intrahepatic cholangiocarcinoma: Simultaneously increased serum values of both AFP and CA19-9 can be detected in few than 10% of patients with pure HCC or pure ICC, 29–45% of those with synchronous HCC-ICC, and one third of patients with cHCC-ICC (Lee et al. 2006; Zhao et al. 2016; Zhou et al. 2008; Cao et al. 2013).