Canalicular and sinusoidal staining for CD10, CD34, and pCEA (polyclonal CEA), along with reticulin framework disintegration, is also characteristic of HCC, as is nuclear positivity for hepatocyte nuclear factor 4 alpha (HNF4a) (Brunt et al. 2015; Gurzu et al. 2015). The gene discussed is HNF4A; the disease is hepatocellular carcinoma.