In cHCC-ICC with predominance of the HCC component, alterations in CTNNB1, promoter of TERT (pTERT), and NFE2L2 seem to be predominant (Calderaro et al. 2023), as an auxiliary argument for the definition of HCC-type cHCC-ICC (Table 3). This evidence concerns the gene CTNNB1 and intrahepatic cholangiocarcinoma.