In cHCC-ICC with predominance of the HCC component, alterations in CTNNB1, promoter of TERT (pTERT), and NFE2L2 seem to be predominant (Calderaro et al. 2023), as an auxiliary argument for the definition of HCC-type cHCC-ICC (Table 3). Here, NFE2L2 is linked to hepatocellular carcinoma.