TLR7 and Autoimmunity: As a control, we also generated THP-1 cells expressing hUNC93B1 with amino acids 530–532 (Pro, Arg, Pro) mutated to alanine (hUNC93B1PRP/AAA), which corresponds to the mutation in the C-terminal tail of mice that we previously showed leads to TLR7-driven autoimmunity (Majer et al., 2019a).