TLR8 and autoimmune disease: Increases in TLR7 or TLR8 gene copy number can induce autoimmune disease in mice (Deane et al., 2007; Guiducci et al., 2013; Pisitkun et al., 2006; Subramanian et al., 2006), and failures in X chromosome inactivation, where TLR7 and TLR8 are located, have been proposed as a cause of SLE in humans (Souyris et al., 2018).