Analysis of 13–15-wk-old mice revealed splenomegaly in Unc93b1R336C/R336C mice (Fig. 4 E), as well as cellular phenotypes consistent with systemic autoimmunity, including expansion of CD11c+ age-associated B cells (ABCs), plasma cells, and monocytes (Fig. 4, F–H). Here, ITGAX is linked to Splenomegaly.