This may partially explain the convergence of clinical phenotypes in UNC93B1 mutant patients on systemic and/or cutaneous lupus disease, given the strong evidence for Tlr7 gene dosage in the severity of murine lupus, and more recent reports of gain-of-function human TLR7 allelic variants associated with SLE (Brown et al., 2022). Here, TLR7 is linked to systemic lupus erythematosus.