In summary, we confirmed that basophil activation and the synthesis of Th2 cytokines IL-4 and IL-13 protect intestinal barrier integrity after P. yoelii infection, thereby controlling MC activation and proliferation and preventing infection-induced intestinal barrier damage, enteric bacterial translocation into the blood, and therefore protecting from and reducing the risk of sepsis (64, 65). The gene discussed is IL4; the disease is infection.