Type 2 innate lymphoid cells are also a major source of IL-13 (44), and both can serve as important sources of IL-4 and mediators of the Th2 immune response in a tissue-specific manner (45), as well as in the context of Plasmodium chabaudi AS infection (46), suggesting that our focus on basophil-derived IL-4 and IL-13 can help to bring greater understanding of basophil-specific effects in malaria. This evidence concerns the gene IL4 and malaria.