Considering the key importance of the above parameters in the functioning of the cardiovascular system and in the view of the close relationship between CacyBP/SIP, β‐catenin and cannabinoid receptors, we decided to compare and evaluate the gene expression and distribution of CacyBP/SIP, β‐catenin, CB1 and CB2 in the adrenal glands of rats with arterial hypertension of various aetiologies. The gene discussed is CNR2; the disease is Hypertension.