ASCL1 and small cell lung carcinoma: The several roles of ASCL1 in the realm of cancer have been made clear by a study by Zhu et al. Specifically, ASCL1 exhibits significantly higher expression in pure small-cell lung carcinoma (P-SCLC) compared to combined small-cell lung carcinoma (C-SCLC), suggesting its potential correlation with histological subtypes of C-SCLC [37].