It is actively involved in transcription regulation, cell cycle regulation, signal transduction, protein folding, and cell division.19 Previous studies have consistently demonstrated that elevated expression of STIP1 is commonly associated with an unfavorable prognosis in various malignant tumors, including HCC, pancreatic cancer, colorectal cancer, gastric cancer, and ovarian cancer.20 The diagnostic value of STIP1 in HCC and ANHC has not been reported. This evidence concerns the gene STIP1 and hepatocellular carcinoma.