An accurate and timely diagnosis can enhance treatment effectiveness considerably and alleviate patient suffering.7 Currently, early diagnosis of HCC relies on the utilization of imaging techniques and serological examination.8 The National Comprehensive Cancer Network clinical practice guidelines suggest that high-risk HCC patients, specifically those with cirrhosis of any cause, should undergo abdominal ultrasound and alpha-fetoprotein (AFP) monitoring twice annually. This evidence concerns the gene AFP and hepatocellular carcinoma.