Genome‐wide association studies (GWAS) and genome‐wide association meta‐analyses (GWAMAs) have recently identified a significant number of new AD risk genes encoding products that predominantly function in endocytic trafficking and signal transduction, such as Bridging Integrator 1 (BIN1), Phosphatidylinositol Binding Clathrin Assembly Protein (PICALM), CD2 Associated Protein (CD2AP), and Sortilin‐related receptor (SORL1).12, 13. This evidence concerns the gene PICALM and Alzheimer disease.