However, a recent study showed significantly higher subgingival Eikenella corrodens levels in lcSSc patients compared to healthy controls, a correlation between Porphyromonas gingivalis and severe periodontitis in lcSSc, and exclusive association of Prevotella intermedia with specific IL-1 gene polymorphisms in lcSSc patients (Jud et al. 2023). This evidence concerns the gene IL1B and periodontitis.